EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A COMPARATIVE STUDY OF EFFICACY OF PREDNISOLONE ACETATE (1%) EYE DROPS ALONE AND WITH CYCLOSPORINE (0.05%) EYE DROPS IN OPTICAL PENETRATING KERATOPLASTY

Neebha Anand*, J. P. Chugh, Jyoti Deswal, Sunil Verma and Rakesh Verma

ABSTRACT

Introduction - Keratoplasty or corneal transplantation is one of the most common and successful tissue transplantations worldwide. Corticosteroids, cyclosporine, and cytotoxic agents are all important therapeutic agents that can be used to treat inflammation and play role in prevention and treatment of graft rejection. Objective - To compare the efficacy of prednisolone acetate (1%) eye drops alone and with cyclosporine (0.05%) eye drops in optical penetrating keratoplasty. Material and Methods-30 patients undergoing optical penetrating keratoplasty in a tertiary health care hospital in north India were randomly divided into two groups. Patients in group 1 were put on prednisolone acetate 1% eye drops post – operatively for 24 weeks. Patients in group 2 were put on prednisolone acetate 1% and 0.05% cyclosporine eye drops for 24 weeks. Follow-up of the patients was done every 2 weeks for 16 weeks, and every month for next 2 months. At each visit, clinical evaluation of the transplanted graft was made and scoring was done for corneal transparency, corneal edema and neovascularisation of graft. Results- At the end of study, 4 patients (26.67%) in group 1 had diffuse marked stromal edema while only 1 patient (6.67%) in group 2 had diffuse marked stromal edema. Maximum number of patients (40%) in group 1 had new vessels invading the graft while in group 2, maximum number of the patients (53.33%) had new vessels invading less than 1/3 recipient bed. 8 patients (53.33%) in group 1 and 10 patients (66.67%) in group 2 had clear cornea. Five patients (33.33%) had white cornea in group 1 while 2 patients (13.33%) had white cornea in group 2. Graft rejection rate was calculated taking into account graft transparency. Graft transparency ≥3 was considered as rejection. At the end of 6 months, 6 patients (40%) in group 1 showed rejection as compared to three patients (20%) in group 2. Overall rejection rate after 6 months was 30%. However, difference in rejection rates between two groups is not statistically significant (p- valve > 0.05). Conclusion- Topical 2% cyclosporine A is an effective adjunct to topical steroids in preventing acute corneal graft rejection episodes or increasing rejection free time interval. But a large multi-centric trial should be carried out to support the evidence.

Keywords: Keratoplasty, prednisolone, cyclosporine, graft rejection.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database