EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

POROKERATOSES- A COMPREHENSIVE REVIEW

Ligi Isac, Song Jiquan*, Hanaasha Kumar and Sufiyan Pottanpulan

ABSTRACT

Porokeratoses are a group of uncommon hereditary or acquired keratinization disorder of unknown aetiology. It is of autosomal dominant inheritance. The known clinical variants include classic porokeratosis of mibelli, disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, linear porokeratosis, Palmaris plantaris punctata, Palmaris plantaris disseminate. The most common one is disseminated superficial actinic porokeratosis (DSAP) which is more commonly seen in women. Porokeratosis of mibelli shows a male predominance. Different variants can coexist in the same patient. Some rare variants have also been reported in the literature which includes PK ptychotropica, follicular porokeratosis, prurigo nodularis like PK, bullous PK, pustular PK, genital PK, seborrheic keratosis like PK, ulcerative PK, eruptive pruritc PK, porokeratoma or porokeratotic acanthoma. The lesions have a predilection for extremities and trunk, but the face, genito-gluteal regions, scrotum, perianal regions are rarely involved. Clinically it is characterized by an atrophic centre surrounded by an elevated keratotic rim. Histologically it is characterized by the presence of cornoid lamellae. Porokeratotic lesions have a greater risk of malignant transformation, localized destruction causing functional impairment. There are several therapeutic options for porokeratoses which helps in the symptomatic improvement and clearance of lesions, but none of them has shown consistent and long-lasting efficacy. In this article, we will discuss about different clinical and rare variants of porokeratosis and the medical efficacy of different therapeutic approaches and also about newer therapeutic options in the treatment of porokeratoses.

Keywords: Porokeratoses, cornoid lamellae, keratinization, variants, laser therapy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database