EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

“FORMULATION AND EVALUATION OF EFFERVESCENT TABLETS OF NSAID AGENT”

Palanisamy. P*, Jaykar. B, Margret Chandira. R, A. Pasupathi, Venkateswralu.B.S

ABSTRACT

The oral dosage forms are the most popular way of taking medication despite having some disadvantages like slow absorption and thus onset of action is prolong. This can be overcome by administrating the drug in liquid from but, many APIs have limited level of stability in liquid form. So, Effervescent Tablets acts as an alternative dosage form. The tablet is added into a glass of water just before administration and the drug solution or dispersion is to be drunk immediately. The tablet is quickly broken apart by internal liberation of CO2 in water due to interaction between tartaric acid and citric acid with alkali metal carbonates or bicarbonates in presence of water. Due to liberation in CO2 gas, the dissolution of API in water as well as taste masking effect is enhanced. The advantages of effervescent tablets compared with other oral dosage forms includes an opportunity for formulator to improve taste, a more gentle action on patient‟s stomach and marketing aspects. In present work an attempt has been made to formulate an effervescent tablet containing immediate release of analgesic and antipyretic drug using various acids and bases. In present work we are used different acids and bases in different concentration. In the preformulation study, compatibility evaluation was performed which implies that drug; acids, bases and other excipient are compatible with each other. The formulation of tablets was done by using wet granulation as well as dry granulation in that technique wet granulation which was found acceptable. The total nine placebo tablets were prepared and evaluated for hardness, disintegration time, weight variation and solubility. All the formulation shows hardness and weight variation with in limit but the combination of citric acid (12.56%), tartaric acid (25.17%), sodium bicarbonate (38.20%), sodium carbonate (6.41%) ,binding agent PVP-K-30 (2.94%) and sodium benzoate (0.52%). for the final formulation, (F7) Because these ingredients shows the good effervescent reaction and has no problem in capping and sticking like other formulation.

Keywords: NSAID Agent, Effervescent tablet, Binding agent-PVP-K-30.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )