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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Isaac John Umaru*, Fasihuddin A. Badruddin and Zaini B. Assim


Objectives: This study was targeted at valuing a claim by traditional herbal practitioner that the leaves of Leptadenia hastata possess ulcer healing property by assessing the effect of Leptadenia hastata on ulcer induced rats. Material and method: The effects of an hexane leaf extracts of Leptadenia hastata were studied in 40 white albino rats over a period of 21days, to ascertain the claim of Leptadenia hastata has ulcerogenic properties, the rats were divided into eight groups those in group one served as control group, group two negative control (Indomethacin) ulcer induced with no treatment, while group three positive control (Omeprazole) and groups four to eight are dosed groups ranged from; 100mg/kg 200mg/kg, 300mg/kg, 400mg/kg and 500mg/kg extracts respectively, Microscopic examination was carried out and scored for the presence of lesion. The length and breadth of the lesion of the stomach was measured for ulcer index. Stomach and Blood sample were collected for Histological, hematological and biochemical analysis. The specimen of the stomach was taken for histopathological studies. Results: The study showed that the extracts of Leptadenia hastata caused increased in the weight of the rats compared to the negative control and the levels of packed cell volume, hemoglobin concentration, red blood cell, white blood cell, mean corpuscular volume and mean corpuscular hemoglobin. The changes in the biochemical parameter were all within the range of the control. Histologically, stomach degeneration was characterized by lesion and decrease number of lining cell of the epithelium. Conclusion: The study indicate that hexane leaves crude extracts of Leptadenia hastata possess ulcer healing activity.

Keywords: Leptadenia hastata, ulcer, rats, histopathology, haematology, serum biochemistry.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia