IN VITRO ANTHELMINTIC ACTIVITY OF NOVEL MANNICH BASES USING
Ch. M. M. Prasada Rao*, V. Nikitha, N. Datta Tejaswi, M. Saiteja, Adimulam Guruprakash and D.
The present study is an attempt to explore the anthelmintic activity of Mannich bases against adult Indian
earthworms, Pheretima posthuma. The time taken for each worm for paralysis and death were determined. Mannich
condensed derivatives MB-06 show effective activity when compared to orientation of standard drug, Piperazine citrate. The time taken for paralysis and death with mannich base-6 at 80 mg/ml was comparable to standard Piperazine citrate.
Keywords: Anthelmintic Activity, Benzimidazole, O-Phenylene Diamine Docking, Tubulin.
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