EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARING CLINICAL AND BIOLOGICAL EFFECTS OF INTRA-ARTICULAR INJECTION OF PLATELET-RICH PLASMA AND HYALURONIC ACID AMONG PATIENTS WITH MILD TO MODERATE KNEE OSTEOARTHRITIS

Dr. Burhan Zafar*, Dr. Jazirah Rehmat, Dr. Javeria Ali, Wardah Rehmat and Waqas Khan

ABSTRACT

Background: Knee osteoarthritis is considered among the common articular diseases. The modern therapeutic methods including the use of platelet-rich plasma (PRP) are responsible for stimulating the healing process of cartilages and improve the damage. Moreover, increase in the incidence of osteoarthritis has forced to conduct this study by assessing long-term impact of intra-articular injection of PRP and Hamon quality of life of the patients suffering from osteoarthritis. Purpose: The main aim of this study is to compare the clinical and biological impact of PRP and HA among patients with mild to moderate knee osteoarthritis. Methods: The study is based on randomized control trial by recruiting 54 patients suffering from knee osteoarthritis. The patients were divided into 2 groups with 26 patients in each group. Group I (PRP injections) PRP intraarticular injections; whereas, group II was administered HA injections. The patients were evaluated before receiving treatment and 6 months after receiving the desired treatment. The results were analyzed through descriptive statistics. Results: The results have shown reduction in pain among both the groups after 6 months of receiving treatment. PRP injections proved to be more effective among the patients with lower grades of osteoarthritis. The VAS scored improved by 50% from its initial value for the group of patients who were administered PRP injections after 3 months of receiving treatment. However, these results were obtained among the patients administered HA injections after a period of 6 months. However, both the treatment modalities improved the knee pain without any statistically significant difference between them. Conclusion: As compared to HA injection, PRP injection was more effective in improving pain after final filtration among the lower grades of osteoarthritis patients.

Keywords: Intra-articular Injection, Platelet-Rich Plasma, Hyaluronic Acid, Knee Osteoarthritis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )