PROGNOSTIC SIGNIFICANCE OF TIA-1 CYTOTOXIC T CELLS VERSUS SIRM IN CUTANEOUS T- CELL LYMPHOMA

A. F. El. Bedewi, MD*, S. S. Sayed, PhD and G. H. K. El. Khalafawy, PhD

ABSTRACT

Background/Purpose: Mycosis fungoides (MF) is the most widespread type of cutaneous T-cell lymphoma (CTCL), yet prognosis stays as a mission. Methods: Twenty MF patients with age range from 16 - 61 years were included in this study; they were diagnosed clinically in the department of dermatology, Cairo University - Egypt. skin biopsy was taken from each patient to confirm the diagnosis, routine investigations and serum LDH were also done. Immunophenotyping using antibodies CD3, CD4, CD8, CD20, CD30 and TIA-1 were evaluated. Further examination with SIRM was done in NSLS, BNL - USA. Statistical analysis was done by Student t-test and Cluster analysis. Results: revealed that both TIA-1 and LDH were correlated with the progression of the disease significantly. Also, both TIA-1 and LDH confirmed that PUVA therapy was significantly effective to all our patients. Furthermore, SIRM proved that different stage of the disease clustered separately and amide was significantly higher in late stage. Conclusion: These findings confirm that both TIA-1 and SIRM detected the cellular changes and they showed a unique biochemical signature within the lymphocytes of MF with the disease progress which could be used as prognostic markers for CTCL.

Keywords: Cutaneous T-cell lymphoma; Mycosis fungoides; Prognosis; SIRM; TIA-1.