EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PROGNOSTIC SIGNIFICANCE OF TIA-1 CYTOTOXIC T CELLS VERSUS SIRM IN CUTANEOUS T- CELL LYMPHOMA

A. F. El. Bedewi, MD*, S. S. Sayed, PhD and G. H. K. El. Khalafawy, PhD

ABSTRACT

Background/Purpose: Mycosis fungoides (MF) is the most widespread type of cutaneous T-cell lymphoma (CTCL), yet prognosis stays as a mission. Methods: Twenty MF patients with age range from 16 - 61 years were included in this study; they were diagnosed clinically in the department of dermatology, Cairo University - Egypt. skin biopsy was taken from each patient to confirm the diagnosis, routine investigations and serum LDH were also done. Immunophenotyping using antibodies CD3, CD4, CD8, CD20, CD30 and TIA-1 were evaluated. Further examination with SIRM was done in NSLS, BNL - USA. Statistical analysis was done by Student t-test and Cluster analysis. Results: revealed that both TIA-1 and LDH were correlated with the progression of the disease significantly. Also, both TIA-1 and LDH confirmed that PUVA therapy was significantly effective to all our patients. Furthermore, SIRM proved that different stage of the disease clustered separately and amide was significantly higher in late stage. Conclusion: These findings confirm that both TIA-1 and SIRM detected the cellular changes and they showed a unique biochemical signature within the lymphocytes of MF with the disease progress which could be used as prognostic markers for CTCL.

Keywords: Cutaneous T-cell lymphoma; Mycosis fungoides; Prognosis; SIRM; TIA-1.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )