EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF ENALAPRIL, LOSARTAN ALONE AND IN COMBINATION ON BLOOD GLUCOSE, SERUM INSULIN AND SERUM CORTISOL IN RABBITS

Dr. Tushar R. Bagle, Dr. Gambre Rohini S., Dr. Shyamal R. Sinha, Dr. Dinesh K. Dhodi, Dr. Abhijeet D. Joshi and Dr. Akash A. Khobragade

ABSTRACT

Introduction: Diabetes is a growing epidemic in greatest number of cases being expected in China and India. Enalapril and Losartan one of the most commonly used antihypertensives were reported to cause hypoglycemia. Material and Methods: 24 albino rabbits were selected after screening and randomized in 4 groups, control (gum acacia), Enalapril, Losartan and combination of Enalapril and Losartan. At zero hours blood collected for baseline investigations, subsequently food administered, followed by drug administration to respective groups. Blood collected at zero (baseline), 1, 2 and 4 hours for blood glucose, serum insulin and serum cortisol levels. Results: The blood glucose levels in Enalapril group was 82.76+0.60, in Losartan (84.85+0.61) and combination of Enalapril and Losartan group (81.26+0.58) showed statistically significant reduction at 1 hour compared to control (98.76+0.64) and similar results were seen at 2 and 4 hours of administering the medication. The Serum Insulin levels in Enalapril (9.93+0.11), Losartan (9.73+0.11) and combination (10.31+0.17) showed statistically significant reduction as compared to control (7.82+0.22) at 1 hour and similar results were seen at 2 and 4 hours. The Serum Cortisol levels in Enalapril (2.36+0.26), Losartan(2.53+0.30) and combination (2.18+0.28) showed statistically significant (p<0.05) reduction at 1 hour as compared to control (3.94+0.38) and similar results were also at 2 and 4 hours. Conclusion: Enalapril, Losartan, alone and in combination has antihyperlycemic effect, this can be used in patients having hypertension with impaired glucose tolerance. These medications also have a chance of causing hypoglycaemia at high doses.

Keywords: Antihyperglycemic, Enalapril, Losartan, Hypoglycemia, Rabbits.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )