EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A COMPARISON OF DICLOFENAC PATCH AND INTRAMUSCULAR DICLOFENAC FOR POSTOPERATIVE ANALGESIA IN ABDOMINAL HYSTERECTOMY UNDER SPINAL ANAESTHESIA-A PROSPECTIVE, RANDOMIZED CLINICAL STUDY

U. S. Gupta*, U. K. Bhagat and A. M. Lakra

ABSTRACT

Introduction: Immediate postoperative period is very crucial and pain is maximum during first 24 hours. If patients are kept pain free during this period, it leads to vitally stable postoperative period which in turn leads to early recovery. The aim of this study was to compare the analgesic efficacy of diclofenac sodium via two different route, intramuscular (IM) and transdermal in the management of postoperative pain. Method: After informed written consent, 60 patients of ASA grade І-III, scheduled for abdominal hysterectomy under subarachnoid blockade were randomized into two groups. Group TP (n=30) received transdermal diclofenac patch 3 hours before surgery and group IM (n=30) received intramuscular diclofenac sodium 30 min before the end of surgery. Transdermal or IM diclofenac were repeated 12 hours later. Postoperative visual analogue scores (VAS), haemodynamic data, requirement of rescue analgesic, patient satisfaction and adverse reaction if any were recorded every 2 hourly over 24 hours period. If VAS values were >4, 2mg/kg tramadol was given intravenously as rescue analgesia. Result: Postoperative VAS, haemodynamic data, requirement of rescue analgesia and patients satisfaction were comparable in both the groups (p>0.05). IM diclofenac has more side effects. Conclusion: Diclofenac transdermal patch provided postoperative pain relief as effectively as IM diclofenac for abdominal hysterectomy, without any significant side effects.

Keywords: Diclofenac, Transdermal, Intramuscular, Postoperative pain and analgesia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia