HERBAL DRUG INTERACTIONS MEDIATED BY P-GLYCOPROTEIN – AN OVERVIEW

Subhashri S. H. R.*, Sridevi R., Monisha P., Shabna E., Vimalavathini R. and Kavimani S.

ABSTRACT

Herbal medicines are widely used for treating various ailments. Many herbs have shown to alter the pharmacological activity of co-administered allopathic medicines thus adversely affecting the clinical efficacy of these drugs. Concurrent use of drugs and herbal products can modulate p-glycoprotein drug transporter either by induction or inhibition of p-glycoprotein pump. P-glycoprotein is a member of the ATP-binding cassette super family of membrane transporters. The review provides an overview of commonly used medicinal and/or dietary herbs which taken part in interaction of the drugs which is mediated by p-glycoprotein.

Keywords: Herbs, drug efflux, p-glycoprotein.