APPROACHES AND EVALUATIONS OF TRANSDERMAL DRUG DELIVERY SYSTEM
K. Malleswari*, R. B. Desi Reddy, G. Ratna Bindu, C. H. Neelima and G. Mounika
A recent approach to drug delivery is to deliver the drug into systemic circulation at predetermined rate using skin as a site of application. Transdermal drug delivery is one of the most promising methods for drug application. Increasing numbers of drugs are being added to the list of therapeutic agents that can be delivered to the systemic circulation via skin. The success of Transdermal therapeutic system has created much interest in the pharmaceutical industry and has activated research activities related to it. Transdermal delivery has many advantages over conventional modes of drug administration, it avoids hepatic first pass metabolism, potentially decreases side effects and improves patient compliance. Drug delivery with Transdermal patch systems exhibit slow, controlled drug release and absorption. The plasma drug concentration does not vary significantly over time. Transdermal delivery system is a growing market that is expected to expand in the near future with the discovery of new drug treatment applications and technologies. The biomaterials research field has broadened in the last 3 decades including drug delivery systems, immunological kits and biosensors. Extensive efforts have been focused on placing a drug delivery system in a particular region of the body for maximizing drug availability and minimizing the dose dependent side effects. Apart from the development of oral controlled release formulations, Transdermal drug delivery systems using thin polymeric membranes have been widely studied. Treatment of chronic diseases such as asthma and rheumatoid arthritis by Transdermal route of drug administration might prove to have several advantages over other routes of drug administration. Plasticization of the membranes can be achieved by blending the polymer with another polymer, by crosslinking or by both crosslinking and blending. The advantages of such polymers are not only to create additional free space to accommodate the drug, but also that these systems are biocompatible.
Keywords: Transdermal Drug Delivery System (TDDS), Skin barriers, predetermined rate.
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