AN OVERVIEW ON NANOSPHERE DRUG DELIVERY

Niba Ibrahim, K. Krishnakumar, B. Dineshkumar and Smitha K. Nair*

ABSTRACT

Delivering of a therapeutic agent to the desired site is a major challenge in treating many diseases. With the emergence of Nanotechnology, it offers drugs in the nano meter size range which has the advantage of enhancing the performance of a wide variety of drugs. Nanosphere is the division of polymeric nanoparticle having size range 10-200nm. They have got many advantages including targeted drug delivery. It can enclose variety of drugs, enzymes, genes and is characterised by a long circulation time. This review briefly explains about formulation aspects including the polymers used for its preparation, different techniques for formulating nanospheres. Also about the characterisation parameters used for the nanospheres. It also gives an idea about the various applications of nanospheres for tumour targeting, brain targeting, gene delivery etc.

Keywords: Nanotechnology, Nanosphere, Targeted drug delivery.