A REVIEW ARTICLE ON URO LITHIASIS IN RATS FOR EXPERIMENTAL STUDY
Dr. Ashish Arun Madavi* and Dr. R. H. Amilkanthwar
Urolithiasis is a common problem afflicted for many centuries with high recurrence. Stone formation in kidney is the oldest and the most widespread medical affliction known to human. The aim of this review is to provide comprehensive information about formation of stone in rats for experimental study. The present study was done to assess the pathophysiology of stone formation. Lithiasis (stone formation) induced by oral administration of 0.75% ethylene glycolated water to adult male albino wister rats for 14 days. The ionic chemistry of urine was altered by ethylene glycol, which elevate the urinary concentration of ions eg. Calcium, oxalate, phosphate, there by contributing renal stone formation. Also discuss about stone forming promoters and inhibiters.
Keywords: Urolithiasis, Male Albino Wister Rats, Ethylene Glycol ETC.
[Full Text Article]