FORMULATION AND EVALUATION OF AN ANTIMICROBIAL DRUG LOADED HYDROGEL MATRIX TABLETS FOR CONTROLLED DRUG DELIVERY
Subadhra Patel* and Dr. Yamini Shah*
The objective of present study was to prepare Ciprofloxacin Hydrochloride (CPH) loaded controlled release matrix tablets using a new polymer combination of Methyl cellulose A4 and Polyox WSR 303 in varying ratios by direct compression technique. Differential Scanning Calorimetry (DSC) measurements were carried out on the drug polymer mix and pure polymers Methyl cellulose A4 and Polyox WSR 303. A 32 Full Factorial design was employed to optimize the matrix tablet formulation of Ciprofloxacin Hydrochloride (CPH) by selecting amount of Methyl Cellulose and Polyox WSR 303 as independent variables and their effects were observed on T50, T90, and % Swelling index. The optimized batch was examined for in-vitro drug release and pharmacokinetics in animals. The antimicrobial activity against B. subtilis and E. coli was determined. The optimized batch gave desired results at 5 hrs as time for 50% drug release at 23 hrs as time for 90% drug release and % swelling index as 45%. The kinetic model fitting of the optimized batch showed Weibull distribution as mechanism of drug release having 0.966 R2 value for CPH from the matrix tablet.Pharmacokinetics (Non- compartmental analysis) in animals revealed Cmax= 3.08 μg/mL, Tmax = 6hr, AUC24= 45.18 μg/mL*hr, MRT = 21.93 μg/mL*hr, T1/2= 13.4 hr and Ke= 0.0154-1. Compartmental analysis showed as per the following Ka= 0.64-1, Tmax = 4.36hr, AUC24= 45.63 μg/mL*hr, MRT = 19.58 μg/mL*hr, T1/2= 1.15hr and Ke= 0.64-1.
Keywords: Controlled release drug delivery, hydrogel tablet, Ciprofloxacin Hydrochloride, matrix tablet, Antimicrobial.
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