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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Subadhra Patel* and Dr. Yamini Shah*


The objective of present study was to prepare Ciprofloxacin Hydrochloride (CPH) loaded controlled release matrix tablets using a new polymer combination of Methyl cellulose A4 and Polyox WSR 303 in varying ratios by direct compression technique. Differential Scanning Calorimetry (DSC) measurements were carried out on the drug polymer mix and pure polymers Methyl cellulose A4 and Polyox WSR 303. A 32 Full Factorial design was employed to optimize the matrix tablet formulation of Ciprofloxacin Hydrochloride (CPH) by selecting amount of Methyl Cellulose and Polyox WSR 303 as independent variables and their effects were observed on T50, T90, and % Swelling index. The optimized batch was examined for in-vitro drug release and pharmacokinetics in animals. The antimicrobial activity against B. subtilis and E. coli was determined. The optimized batch gave desired results at 5 hrs as time for 50% drug release at 23 hrs as time for 90% drug release and % swelling index as 45%. The kinetic model fitting of the optimized batch showed Weibull distribution as mechanism of drug release having 0.966 R2 value for CPH from the matrix tablet.Pharmacokinetics (Non- compartmental analysis) in animals revealed Cmax= 3.08 μg/mL, Tmax = 6hr, AUC24= 45.18 μg/mL*hr, MRT = 21.93 μg/mL*hr, T1/2= 13.4 hr and Ke= 0.0154-1. Compartmental analysis showed as per the following Ka= 0.64-1, Tmax = 4.36hr, AUC24= 45.63 μg/mL*hr, MRT = 19.58 μg/mL*hr, T1/2= 1.15hr and Ke= 0.64-1.

Keywords: Controlled release drug delivery, hydrogel tablet, Ciprofloxacin Hydrochloride, matrix tablet, Antimicrobial.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database