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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



D. U. C. Rahayu, Silmi Nurul Adilah and P. Sugita*


Objectives: Temu giring (Curcuma heyneana) is widely used as herbal medicinal plant to treat stomach aches and skin diseases. The objectives of this study are to report the chemical structure and antioxidant activity of the polar fraction of this particular species. Material and Methods: The crude methanol extract was fractionated by vacuum liquid chromatography with gradient elution to produce 10 fractions. Fraction F and H were separated by various chromatography technique giving F121 and H13. Results: Identification of F121 and H13 with liquid chromatography–mass spectrophotometry (LC-MS) showed 3 compounds in F121 and 2 compounds in H13. The compounds were identified as curcumanolide A, (R)-ar-turmerone, (1(10)-E,4β,5α,8β)-4,5-epoxy-1(10),11(13)-germacradien-12,8-olide, Dihydrosuberenol, and demethoxycurcumin. Dihydrosuberenol had been reported in this species, while the other compounds had been found in the same genus. The result of the antioxidant activity toward 1,1-diphenyl-2-picrylhydrazil (DPPH) showed moderate activity of H13 and its crude methanol extract with IC50 59.18 and 82.16 μg/mL, respectively, while the F121 showed a low antioxidant activity with IC50 value > 100 μg/mL. Conclusions: analysis of Indonesian C. heyneana rhizomes gave sesquiterpenes of germacrane, cyclic sesquiterpenoid types, and coumarine compounds and have potency as antioxidant activity.

Keywords: Curcuma heyneana, germacrane, cyclic sesquiterpenoid, coumarine, antioxidant activity, IC50.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia