EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NASOPHARYNGEAL CARCINOMA IN TUNISIAN CENTRE: ABOUT 712 CASES LE CANCER DU CAVUM DANS LE CENTRE TUNISIEN: A PROPOS DE 712 CAS

Sarra Ouni*, Nadia Bouzid, Nourra Khaireddine, Mohamed Abdelkefi and Noureddine Bouaouina

ABSTRACT

Purpose: The current retrospective study detail the various epidemiological, clinical, therapeutic and prognostic factors of nasopharyngeal carcinoma (NPC) in the center of Tunisia. Materials and Methods: The study concerned 712 patients with confirmed NPC treated between 1995 and 2013 in department of radiation oncology Hospital Farhat Hached of Sousse and the medical center Ibn Khaldoun Hammam Sousse. Survival rates were calculated using the Kaplan Meier method, and the differences were compared with the log rank test. Multivariate analysis was performed with the Cox regression model to identify independent factors. Results: The median age at presentation was 47 years, the most common presenting symptom was a palpable neck lump (70, 9%) and the median duration of symptoms was 7, 2 months. The predominant histological type was undifferentiated carcinoma (UCNT). According to the classification TNM 2010, the tumors are divided into T1 in 43.3% of cases, T2 in 25%, T3-T4 in 30, 6%. 7, 3% of patients was metastatic at presentation (bone metastasis 90, 3%). the 5-year overall survival, recurrence-free survival and metastasis-free survival were, respectively, 60.3%, 89.2% and 80.1%. Conclusion: In our series were noted good results in terms of local control and overall survival. The treatment is mainly based on the multimodal chemotherapy and radiotherapy association. High radiation doses are associated with excellent local control at the cost of late toxicities which become more important for the young population.

Keywords: Nasopharyngeal carcinoma; Radiotherapy; Chemotherapy; Prognostic Factors.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing