EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF OXIDATIVE STRESS, GONADOTROPHINS AND PROLACTIN IN INFERTILE WOMEN

Abubakar A. Panti*, Ateeque B. Umar, Umar A. Rabiu, Yusuf Saidu, Lawal S. Bilbis, Constance E. Shehu, Karima A. Tunau and Mairo Hassan

ABSTRACT

Background: Reactive oxygen species are implicated in the pathogenesis of many diseases but their role in female infertility has not been extensively established. Objective: To determine oxidative stress markers, in infertile and fertile controls. To determine the level of gonadotropins and prolactin in both groups. Methodology: The study was a case control study conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. This study determined serum levels of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) using standard methods in 100 females, among whom 50 were infertile and the remaining 50 were fertile (control) subjects matched for age. Results: All the infertile subjects showed significantly (P<0.05) higher levels of MDA (5.92±0.39 vs 1.35±0.09) with lower levels of antioxidant enzymes compared to the fertile controls (CAT: 24.65±2.20 vs 104.14±2.24; GPx: 7.66±0.13 vs 25.24±0.55) except SOD (0.51±0.03 vs 0.65±0.03). FSH, LH and PRL levels showed significantly lower levels in the infertile subjects (FSH: 17.13±1.23 vs 6.80±0.45; LH: 18.38±1.23 vs 5.76±0.41; PRL: 33.84±4.14 vs 18.38±1.23). Conclusion: Women with infertility have high oxidative stress status and low level of antioxidant compared to control. In light of this, antioxidant supplementation to infertile women is recommended as a strategy to enhance their chances of conception.

Keywords: Reactive oxygen species prolactin in both groups.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing