DESIGN AND DEVELOPMENT OF MULTI-PARTICULATE TABLET FORMULATION OF ACE INHIBITOR FOR CHRONOTHERAPY
Kartik Shah*, Madhu Raj Sharma and Dr. Shailendra Sharma
The aim of the present study was to develop a chronotherapeutic drug delivery system containing enalapril maleate, an ACE inhibitor, enabling two pulse drug release for management of early morning high blood pressure. MUPS Tablet formulation has been prepared containing two different kind of pellets i.e. drug containing core pellets for immediate release and delayed release polymer coated pellets for providing pulse release after a predetermined lag time. Compression of pellets into MUPS tablets present certain challenges. The study design developed to obtained information on effect of different cushioning agents with its range on drug release profile from MUPS tablets. In addition of pellet size, comparison of pellets prepared with different techniques, effect of different % polymer coating , effect of pegylation above polymer coat on compression was also been evaluated. Silicified MCC with around 50 % w/w concentration of tablet weight along with PEGylated DR pellets identified for targeted pulsatile drug delivery system. And obtained chronotherapeutic formulation can be enable to treat nocturnal hypertension.
Keywords: MUPS; Pulsatile drug delivery; Chronotherapeutic formulation; Pellet; ACE inhibitor.
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