EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF STABILIZED BETA-CAROTENE 7.5% DISPERSION IN MULTIVITAMIN SYRUP

M. Rajesh*, Nadar Antonprisca Jeyapaul and P. Ramkumar

ABSTRACT

In most of the multivitamin oral syrups, there are instability problems of vitamin A with vitamin D and E. Beta-carotene (precursor to vitamin A) has poor stability and several studies had reported that Beta-carotene 7.5% dispersion was not stable in multivitamin syrup formulations. So the main objective of the study was to formulate and stabilize Beta-carotene 7.5% dispersion in multivitamin (Vitamin D and E) syrup formulations. Two formulations (B1 and B2) of Beta-carotene 7.5% dispersion syrups were developed. The formulated syrups were evaluated for appearance, colour, taste, pH, wt/ml, viscosity and drug content. Formulation B2 showed good results in terms of general, physical and chemical parameters evaluated compared to formulation B1. Hence, formulation B2 was considered as an optimized formulation. Multivitamins (Vitamin D & E) was incorporated in the optimized formulation (B3) and the stability of formulation B3 was evaluated in terms of general, physical and chemical parameters. The stability reports of formulation B3 revealed that Beta-carotene 7.5% dispersion was stable even in presence of multivitamins. The study thus concludes that stable formulations of multivitamin syrup with Beta-carotene 7.5% dispersion could be successfully developed.

Keywords: Beta-carotene, Multivitamins, Optimized formulation, Syrup.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia