DESIGN, SYNTHESIS AND CHEMICAL HYDROLYSIS STUDY OF CODRUGS OF PROPRANOLOL WITH METFORMIN.
Ganesh S. Andhale*, Giles D., Amit K. Das, Anirbandeep Bose and Basavraj Metikurki
In the present study we have synthesized ester prodrugs (Pa-h) of Propranolol (I) by using pthalic anhydride and derivatives of succinic and maleic anhydride. Different codrugs (COa-h) were synthesized from prodrugs of propranolol. All the codrugs were characterized by melting point, FTIR, NMR and Mass Spectroscopy. The chemical hydrolysis of COa-h were investigated at the pH 1.2, 6.8 and 7.4. Presence of maleate, methyl maleate, dimethyl maleate and succinate group as linker possess high hydrolysis when compared to that of other substitutes. Among the synthesized codrugs, COd is found to be the best one among the series.
Keywords: Chemical hydrolysis, codrugs, metformin, prodrugs, propranolol.
[Full Text Article]