FORMULATION AND OPTIMIZATION FLOATING TABLETS OF APRICITABINE BY USING COMBINATION OF POLYMERS SUCH AS GANTREZ MS AND HPMC

Shireesh Kiran R.*, Chandra Shekar B. and Nagendra Babu B.

ABSTRACT

The principle of the present work was to develop, optimize gastric floating drug delivery system (GFDDS), in vitro, and in vivo evaluation of containing Apricitabine as a model drug and using polymer blend derived from Gantrez ms and HPMC. The effects of independent variables on dependent variables, i.e. floating time, total floating time (TFT), and diffusion exponent (n) and mean residence time (MRT) in the stomach were evaluated. Twenty formulations were prepared, by changing the concentration of Gantrez AN-119, Gantrez MS-995, Gantrez S-97 and HPMC K100M, HPMC K15M from this optimized formulation was found by in vitro dissolution studies obtained was applied to the Zero order, First order, Higuchi and Krosmeyer–Peppas equations. The invivo studies of optimize formulation and 2% of suspension was evaluated as float duration up to 24hrs and sustained drug release was obtained. It can be concluded that floating matrix tablet of Apricitabine prepared by using Gantrez ms and HPMCK100M has possible for sustained release of the drug as well as enhanced oral bioavailability through better gastric residence time of formulation in stomach of rabbits.

Keywords: Gantrez ms and HPMC.