EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

BRONCHIAL ASTHMA AND SERUM MAGNESIUM: A COMPARATIVE STUDY IN STABLE AND EXACERBATING CLINICAL CONDITION.

Dr. Nadeem Shaikh*, Dr. Ruchi Gokani, Bhavita Patel, Brahma Reddy

ABSTRACT

Background: Asthma is one of the most common diseases and one of the major causes of morbidities which demands high cost.With improvement in research and management methods,electrolyte imbalance is found to to be linked with exacerbation of asthma and lead to severe complications and even death.Magnesium ion has an inhibitory action on smooth muscle contraction,histamine release from mast cells and acetylcholine release from cholinergic nerve terminals.Magnesium has been shown to relax bronchial smooth muscles and influence the function of respiratory muscles.Hypomagnesemia have been associated with diminished respiratory muscle power. Aim: To assess the serum Mg levels in bronchial asthma patients during stable and exacerbating clinical conditions. Subjects and methods: 80 Subjects were enrolled, 40 patients diagnosed as bronchial asthma and 40 healthy individuals as a control group. The asthmatic patients were divided into group (I) chronic stable bronchial asthma and group (II) acute exacerbation of bronchial asthma. Results: Serum Mg levels were significantly lower in asthmatic patients compared with healthy controls and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics. There was a positive correlation between serum Mg levels and each of FEV1/FVC ratio and FEV1. Conclusion: Serum magnesium level should be monitored in the patients of bronchial asthma and hypomagnesemia should be treated along with bronchodilator therapy. Abbreviations: BMI-Body mass index; FEV1-Forced expiratory volume in the 1st second;FVC-Forced vital capacity; LABA-Long Acting B2 Agonist; ICS- Inhaled Corticosteroids;SABA-Short Acting B2 Agonist.

Keywords: Magnesium; Bronchial asthma; Stable; Exacerbation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )