EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

ANTIUROLITHIATIC ACTIVITY OF GREWIA FLAVESCENS JUSS. ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN RATS.

G. N. Pramodini*, Dr. Shaik Mohammed Khasim and Dr. Parwez Alam

ABSTRACT

Objective: To study the antiurolithiatic activity of grewia flavescens (tiliaceae) in ethylene glycol induced urolithiasis in male wistar rats. Method: The urolithiasis was induced in rats by oral feeding of ethylene glycolated water (0.75%) for 28 days. Ethanolic extract of EEGF (100mg/kg, 200mg/kg, and 400mg/kg) was administered orally from 1st day to 28th. Results: it was observed that the inducing agent ethylene glycol elevated the formation of kidney stones and kidney inflammation which resulted in decrease in urine output. Treatment with ethanolic extract of EEGF from 15th days significantly (P<0.001) reduced the kidney stones and resulted in restoring of kidney activity such as glomeruli and renal tube functioning. Conclusion: 28 days administration of ethylene glycol showed calcium oxalate crystals in renal tubules in negative control group. Treatment with EEGF decreases the calcium oxalate crystals on dose dependent manner and restored activity of glomeruli and renal tube functioning. Thus the results of our study reveal that EEGF effective in treatment of ethylene glycol induced urolithiasis in rats when compared to the standard drug cystone.

Keywords: Antiurolithiasis, Grewia flavescens, Tiliaceae, Ethylene glycol.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia