GENE THERAPY – A REVIEW
*Ayush Garg, Salil Sanghvi, Krunal Trivedi and Hitesh Chaturvedi
The ability to transfect genes into cells and to cause their expression is leading to the practical emergence of human
gene therapy, wherein, functionally active genes are putatively inserted into the (somatic) cells of a person
requiring the expression of a given protein. A novel adaptation of gene therapy is the transfection of cells with nonresident
genes in order to accomplish in situ expression of a pharmacologically beneficial protein or create a site
for further therapeutic intervention. In other words, genes would act like drugs, generating a product with a specific
pharmacological effect. In simple terms, gene therapy involves insertion of genetic material into a patient’s cells to
make them capable of producing therapeutic protein.
Keywords: Gene, germ line, somatic, retrovirus, vectors.
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