NEW SPECTROPHOTOMETRIC ESTIMATION OF NIMESULIDE IN THE TABLETS USING MIXED SOLVENCY APPROACH
Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi
Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution.
Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in
spectrophotometric estimations. In the present investigation, it was proposed to solubilize Nimesulide by use of
mixed solvency concept. Nimesulide shows maximum absorbance in the concentration range of 10-50μg/ml at 390
nm. Method of analyses have been validated for different parameters like linearity, accuracy, precision, LOD and
LOQ. The percent drug estimated in tablet formulation of Batch-I and of Batch-II were 100.16±0.260and
99.96±0.283 respectively. The range of percent recoveries varied from 100.36±0.175 to 101.23±0.371.Sodium
Benzoate and phenol do not interfere above300 nm. The analytical method was found to be simple, safe (free from
toxicity), economic and eco-friendly.
Keywords: Nimesulide, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept.
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