ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACTS OF CORMS OF COLOCASIA ESCULENTA VAR ESCULENTA
Md. Hamidul Islam, Mohd. Najib Mostafa and Mohammed Rahmatullah*
The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Colocasia
esculenta var esculenta (Bengali: Panchamukhi kochu) corms in glucose-loaded mice. Antihyperglycemic activity
was determined through oral glucose tolerance test (OGTT) in mice. Oral administration of methanol extract of
Colocasia esculenta var esculenta corm (MECEE) at doses of 50, 100, 200, and 400 mg per kg body weight each
to glucose-loaded mice dose-dependently reduced blood glucose levels by 15.1, 24.4, 32.1, and 35.8%, respectively
compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when
administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 41.8%. Methanolic extract of
corms of Colocasia esculenta var esculenta can improve oral glucose tolerance and thus is effective in lowering
elevated blood glucose levels, which can prove beneficial for diabetic patients.
Keywords: Antihyperglycemic, Colocasia esculenta var esculenta, glibenclamide, OGTT.
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