EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

DOCKING STUDIES OF BCL-2 WITH HEMIDESMUS INDICUS COMPOUNDS FOR ANTI-CANCER STUDIES

B. Kutumbarao* and Veeravilli Suryanarayana

ABSTRACT

Medicinal plants have wide spread properties due to the presence of phytocompounds and are the alternative medicines available for thosewho cannot be helped by conventional medicine. In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Gas chromatography and Mass Spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Out of twenty selected compounds, docking results showed Methyl-1-Cyclo Hexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

Keywords: Anticancer, BCL-2, Docking studies, Hemidesmus indicus, Insilico studies.

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