NATURAL CONTRACEPTIVE FOR MALE RATS

*Atef E. Abd El-Baky

ABSTRACT

Many plants have therapeutic actions for some diseases and also, it has adverse effects which can be employed to solve another some problems. This study is aimed mainly on the adverse effect of Citrullus-colocynthis on fertility. Where, fertility control is essential and concerned with national public health. Methods: Thirty male rats were divided into 3 groups, 1st group was kept as control, 2nd and 3rd groups received C-colocynthis extract orally (50 mg, 150 mg /100g B W respectively) day after day for 70 days. Results: There was an increase in hepatic lactate dehydrogenase (LDH), protein thiols (Pr-SHs), reduced glutathione (GSH), glutathione peroxidase (GPx) and superoxid dismutase (SOD). Also, there was an increased in hepatic total protein, albumin, globulin and adenosine triphosphate (ATP) in liver homogenate as compared to the control. The testes weight and the values of deformed head sperm showed an increased. In treated groups the results showed a decreased in sperm number, motility and the number of life sperm in compared with control. Histopathological examination showed some changes in seminiferous tubule with some degenerative changes. Conclusion: C-colocynthis extract had anti-fertility effects on male rats in addition to its antioxidant effects and increasing of ATP and liver protein content.

Keywords: Seeds, Extract, Fertility, Public health, Sperm.