EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ADVERSE CUTANEOUS DRUG REACTION: STUDY OF 200 CASES FROM TERTIARY CARE HOSPITAL

Krina Bharat Patel* Ruchin B Patel

ABSTRACT

Background: Adverse cutaneous drug reactions (ACDRs) are caused by a wide variety of agents and in different forms. Aims: Our objective was to assess the clinical spectrum of ACDRs and to find out the causative drugs in patients of tertiary care hospital. Methods: 200 patients with ACDR presenting in skin OPD between 2005 – 2011 were included in this study. Type of drug reaction and offending drugs were noted. Routine hematological and biochemical investigations were done in all patients. S. VDRL and S. HIV tests were done as when indicated. Histopathology was done in cases which required confirmation. Results: The Mean age of patients with ACDR was 38.26 years. Highest number of patients (26.5%) were reported in 41-50 years of age. The male to female ratio was 1.4:1. The most common pattern of ACRD was urticaria and/or angioedema (33.5%) . Co-trimoxazole and Diclofenac were most common culprit drugs. Many rare and severe type of ACDR like acute generalized exanthematous pustulosis and drug induced rash with eosinophilia and systemic symptoms were found in our series. Conclusion: Identifying drug reaction at early stage and finding out culprit drug is essential for physician for preventing disability arising out of ACDR and also to morbidity and mortality due to complications of ACDR.

Keywords: Adverse cutaneous drug reaction, drug rash, drug reaction


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )