EVALUATION OF DIABETIC COMPLICATIONS, NEURO, HEPATO, CARDIO AND NEPHRO PROTECTIVE EFFECTS OF ETHANOLIC EXTRACT OF THE WHOLE PLANT OF TAXILLUS TOMENTOSUS IN ALLOXAN INDUCED DIABETIC RATS

Mohammed Nayeem Uddin*, Mohammed Wahab Uddin, Firasath Ali.

ABSTRACT

Diabetes mellitus (DM) is a world's fastest growing metabolic disease with high prevalence worldwide; associated with markedly increased morbidity and mortality rate and reduced the quality of life. It is the third commonest disease in the world affecting approximately 2.8% of global population. Persons with diabetes are at increased risk for macro vascular and micro vascular disease. Currently available synthetic antidiabetic agents produce serious side effects. This leads to a demand for herbal products with antidiabetic activity and fewer side effects. Hence the effects of oral administration of ethanolic extract of Taxillus tomentosus has been studied in alloxan induced diabetic Wister albino rats. The diabetic rats treated with ethanolic extract of whole plant of Taxillus tomentosus Tiegh with low dose and high dose, Metformin orally as an anti-hyperglycemic standard for 14 days. Test extract exhibited a significant dose dependent anti hyperglycaemic activity compared to diabetic control which is less potent than reference standard metformin. The results indicate that the ethanolic extract of Taxillus tomentosus is endowed with antidiabetic activity.

Keywords: Taxillus tomentosus, Hyperglycemia, Alloxan, Diabetic complications, allodynia.