EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF INTRACAMERAL INJECTION OF DEXAMETHASONE IN PEDIATRIC CATARACT SURGERY

Hassan Shamselden Yousef M.D., Ahmad Abdel Karim Mohamed M.D. and Asaad Noor Eldin M.D.

ABSTRACT

Purpose: to evaluate the role and safety of intracameral injection of dexamethasone phospate 0.1cc (0.4mg) at the end of cataract surgery in prevention of postoperative inflammation and improvement of surgical outcomes in pediatric cataract surgery. Methods: a hospital based interventional comparative study was performed on 30 eyes of 26 patients with pediatric cataract. The patients were divided into two groups of equal size on the basis of simple random sampling. Group 1 (Gp.I): It included 15 eyes who were given routinely subconjuctival injection of dexamethasone 2mg and gentamycin 20mg at the end of cataract surgery. Group 2 (Gp.II): It included 15 eyes who were given subconjuctival injection of gentamycin (20mg) and intracameral injection of dexamethasone phosphate 0.1cc (0.4mg) at the end of cataract surgery. All patients were be scheduled for 6 months for evaluation of the degree of intraocular inflammatory response, fibrinous reaction, exudative membrane, synechiae formation, corneal oedema, Kps, posterior capsular opacification and Intraocular pressure were be also monitored at each visit Results: AC cells and flare were markedly decreased in dexamethasone group, Also the incidence of postoperative membrane formation about (20%), postoperative synechia formation about (20%), postoperative corneal edema about (13.33%), postoperative keratic precipitates (Kps) about (6.66%) and posterior capsular opacification about (20%) in group II as compared with group I. Thier was no serious adverse effect noticed from the intracameral injection of dexamethasone. Conclusion: the use of intracameral dexamethasone phospate 0.1cc (0.4mg) at the end of pediatric cataract surgery was found safe and superior to subconjuctival injection of dexamethasone in decreasing early postoperative inflammation, membrane and synechia formation and also posterior visual axis opacification.

Keywords: .


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