EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANALYSIS OF SIGNAL NETWORKS IN HEMATOPOIETIC STEM CELLS DETERMINING THE STEM CELL FATE

Swati Sharma, Gurudutta U. Gangenahalli* and Upma Singh

ABSTRACT

Hematopoietic stem cells (HSCs) are the unique cells having the core property of self-renewal/ proliferation and differentiation which make them capable of giving rise to all blood cell lineages. Proliferation and migration of HSCs in a regulated manner maintain healthy homeostasis by the interplay between differentiation, self-renewal/ proliferation and dormancy. Here, we identified and described functional molecular signatures eliciting different biochemical responses in molecular signaling of CD34+ HSCs in response to a cocktail of Interleukin-3 (IL-3), Fms-Like Tyrosine Kinase-3 Ligand (FLT-3), and Stem Cell Factor (SCF), using a network-based approach. The bioinformatic analysis of sum total of 22,283 gene transcripts (extracted from microarray data GSE3003) resulted into the characterization of genes (in two subgroups: up-regulated & down-regulated) eliciting stem cell responses: proliferation, differentiation and self-renewal. As in-vitro proof of concept, nine significant genes, RBM3, DHX32, PSMD9, SAR1A, SMYD3, ST6GAL1, CKAP4, CTR9 are selected for further analysis, having a key role in molecular signaling. Taken together, our results showed the identification of some novel regulatory genes through computational means and their functional importance in biological pathways.

Keywords: Hematopoietic stem cells (HSCs), self-renewal, proliferation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )