EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE ANALYSIS OF ANTITHROMBOTIC EFFECT OF ETHANOL EXTRACT AND ITS DIFFERENT FRACTIONS OF STERCULIA CORDATA LEAVES

Syed Md. Abdul Kader, Md. Imdadul Haque*, Shababa Wajida Nihar, Mahmudul Hasan, Abid Newaz Shihab, Fatema Akhter, Nazia Hassan and Tajmira Zaman

ABSTRACT

Background: The purpose of the investigation was to ascertain whether the leaf extract and fractions of Sterculia cordata holds any significant antithrombotic properties. Methods: Leaves of Sterculia cordata was extracted with pure ethanol (EESC) then ethanol extract fractioned with methanol (MFEESC), n-hexane (NHFEESC) and chloroform (CHFEESC). The antithrombotic activity of the extracts and fractions were evaluated by clot lyses test using the standard streptokinase on human blood. Results: Using an in vitro antithrombotic model, all extracts, fractions, and Streptokinase exhibited significant (P < 0.0001) clot lysis. EESS showed the highest significant (62.04 ± 2.10%) clot lysis activity among all the extracts (P > 0.0001 compared to negative control and P > 0.001 compared to positive control), which is highest compared with other sample treatment. Conclusions: The overall results of the study indicated significant antithrombotic activity of different extracts and fractions of leaves of Sterculia cordata. Furthermore, this plant deserves further investigation for other paramount pharmacological activities and comprehensive research and isolation of the active constituents responsible for these activities and establishes the mechanism of action.

Keywords: Sterculia cordata, antithrombotic, extract, fraction.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )