EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREVALENCE OF METALLO BETA LACTAMASE (MBL) PRODUCING PSEUDOMONAS SPECIES AMONG CLINICAL SAMPLES FROM S.V.R.R.G.G.HOSPITAL, A TERTIARY REFERRAL HOSPITAL OF S.V. MEDICAL COLLEGE, TIRUPATI.

Dr. Ediga .V. Lavanya, Dr. Gandikota Rajaram*, Dr. Tippireddy Palli Gururaju,
Dr.  Boddu Maha Lakshmi4, Dr. Sharabu Yamini, Dr. CH. Srinivasarao.

ABSTRACT

Hospital-acquired infections are a major challenge to patient safety. Carbapenems are one of the best for the treatment of critically ill patients. Patients treated with routine antibiotics for Metallo-beta-lactamases (MBL) producing Pseudomonas aeruginosa strains resulted several nosocomial outbreaks in tertiary referral hospitals and poor patient outcome. Early detection of metallo-beta lactamase (MBL) producing Pseudomonas aeruginosa among critically ill hospitalized patients is crucial for optimal treatment and to prevent the spread of resistance. The present study was done over a period of one year from January 2011 to December 2011, in the Department of Microbiology, S.V. Medical College, Tirupati. 200 non repetitive Pseudomonas species were isolated from clinical specimens based on standard tests. Antimicrobial sensitivity was performed by Kirby-Bauer disk diffusion method and evaluated for multidrug resistance and screened for MBL production by combined disk diffusion test (CDDT) using imipenem (IMP), and imipenem (IMP) with EDTA. Among 200 Pseudomonas isolates 22 (11 %) were identified to be MBL producers and 75 (37.5 %) were multi drug resistant (MDR). All the MBL positive strains were belonging to this MDR group constituting 29.33%. All MBL strains were resistant to ceftazidime and imipenem and 95.45% of strains of MBL were resistant to carbenicillin. Early detection of MBL-production among Pseudomonas isolates may help to initiate appropriate antimicrobial therapy and to prevent the development and dissemination of these multi drug resistant strains.

Keywords: Pseudomonas aeruginosa, Metallo-beta-lactamase (MBL) Imipenem-EDTA combined disc diffusion test (CDDT).


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )