EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE STUDY OF CLINICAL PRESENTATION, MORBIDITY PROFILE AND OUTCOME WITH H1N1 INFLUENZA A IN ADMITTED CHILDREN

Yudhavir S. Shekhawat*, Anurag Singh and Pramod Sharma

ABSTRACT

Background- Influenza virus is a common human pathogen that has caused serious respiratory illness and death. In April 2009 a new strain of Influenza virus A H1N1 began to spread in several countries around the world and India confirmed its first case on 16 May 2009. The 2013-2014 influenza season was marked by the resurgence of pandemic A/H1N1virus causing substantial morbidity and mortality around the world. Objective- The study of clinical presentation, morbidity profile and outcome of H1N1 influenza A in admitted children of a Tertiary health centre. Methods-130 patients satisfying the WHO criteria of CAP were enrolled. Nasopharyngeal Aspirates of these patients were tested for H1N1 virus by using the Real Time Reverse Transcriptase Polymerase Chain Reaction assay. Clinico-epidemiological profile and outcome of positive patients were analysed. Results- Twenty-three (17.7%) patients were confirmed (positive) for H1N1influenza A. Maximum 13(56.5 %) patients were in the age group 1-5 years. Male (73.9%) were affected more than Females (26.1%). The common symptoms were rapid breathing (100%), fever (82.6%) and cough (95.7%). Malnutrition was present in 10 (43.5%) cases. Total 3 (13.0%) patients were taken on mechanical ventilator, out of them no one survived. Conclusion- Clinician should consider H1N1 influenza A in the differential diagnosis of patients who presented with acute onset of fever, cough and breathlessness. The routine laboratory investigations in children with H1N1 influenza A were non-specific. There was no specific laboratory characteristic shown to have a significant association with the severity of illness or poor outcome. Poor prognostic factors as derived in the current study were the development of ARDS, need of mechanical ventilation and associated co-morbid illness.

Keywords: H1N1 influenza A, Community Acquired Pneumonia (CAP), (RT-PCR) Real Time Reverse- Transcriptase Polymerase Chain Reaction.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )