BILAYER TABLET - AN EMERGING TREND
Shaikh Aamer Khaleel, P. R. Patil*, P. R. Mahaparale and Monika Bhagat
Bilayer tablet technology is a new emerging era, in the pharmaceutical industry. Over a past few decades, around 90% drugs have been formulated for the purpose of oral delivery. Oral ingestion is the most convenient and commonly employed route of drug delivery, due to its ease of administration, high patient compliance, cost effectiveness, least sterility constraints, and flexibility in the design of dosage form. Due to these properties oral dosage form has gained much attention and became the popular class of formulation worldwide. Bilayer tablets do offer a definite advantage over conventional release formulations of the same drug. So as to overcome the problems associated with the conventional dosage form, there arose an interest in developing the controlled drug delivery system. Bilayer tablet technology can be a crucial way to avoid tablet chemical incompatibilities between API’s by physical separation, and to facilitate the development of different drug release profiles, also involves the combine effect of slow release with the immediate release formulations. By adding an inert intermediate layer, the two incompatible drugs can be formulated. Drugs which are formulated in the form of biphasic system have different biological applications such as analgesic, antipyretic, antiallergenic, coronary vasodilators, antihypertensive and anti-histaminic. This review deals with the various modern technologies, marketed formulations and patented formulations in the form of bilayer tablet which facilitates the need of researchers in the development of new bilayer tablet formulations.
Keywords: Bilayer tablet, physical/layer separation, chemical incompatibilities.
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