ROLE OF PARAOXONASE ENZYME STATUS IN CORONARY HEART DISEASE IN THE AL- QUWAYIYAH REGION OF SAUDI ARABIA

Dr. Ramprasad Nagarajrao*

ABSTRACT

Background: Coronary Heart Disease (CHD) is a principal cause of mortality and disability globally. Dyslipidemia and lipid peroxidation are considered an independent risk factor for CHD. Serum Paraoxonase (PON) enzyme is almost exclusively located on the high density lipoprotein (HDL). It will protect against LDL oxidative modification in atherosclerotic lesions and atherogenic indexes in CHD patients and healthy peoples. Methods: An open randomized study was case controlled in design. The present study included 60 patients suffering from CHD and 65 age and sex matched healthy controls were included during the period of December 2016 to October 2017. Various parameters like lipid profile, lipid peroxidation marker i.e. malondialdehyde (MDA) and antioxidant enzyme PON levels were measured and compared. Results: Increased levels of MDA concentration, total cholesterol, triglycerides, LDL-cholesterol, while decreased levels of HDL- C and PON were significantly low (p<0.001) in CHD patients compared to normal healthy controls. Conclusion: The study showed strong evidence of CHD associated with low activity of PON and HDL-C and significantly a high level of lipids and lipid peroxides concentrations, atherogenic index, atherogenic coefficient and cardiac risk ratios may be involved in the early pathogenesis of CHD. The present study illustrated that the PON is an important enzyme in oxidant - antioxidant status of atherosclerosis with its antioxidant effect.

Keywords: Coronary heart disease, Lipid profile, Malondialdehyde, Paraoxonase.