FORMULATION AND EVALUATION OF INTRA NASAL IN SITU MUCOADHESIVE GEL OF DOMPERIDONE MALEATE

Mathew George, Lincy Joseph and Kavitha A. K.*

ABSTRACT

The prolonged residence of drug formulation in the nasal cavity is of outmost important for intra nasal drug delivery. The objective the present study was to develop a mucoadhesive insitu nasal gel with reduced nasal mucocilliary clearance inorder to improve the bioavailability of the antiemetic drug, domperidone maleate. The insitu gelation upon contacted with nasal mucosa was conferred via the use of of the thermogelling ploxomar 407 where as mucoadhesive and drug release enhancement were modulated via the use of sodium alginate and PEG 6000 plymers respectively. The result revealed that the mucoadhesive polymers increased the gel viscosity but reduced its sol gel transition temperature and the drug release. The inclusion of PEG plymers counteracted the effect of mucoadhesive polymer were by it decreased the gel consistency and increased the sol gel transition as well as invitro drug diffusion. The invitro test performed for mucoadhesive strength and drug diffusion showed that nasal insitu gelling formulation prepared are good mucoadhesive strength with nearly 85% drug diffusion within 8 hours. So this study provides ease of administration, accuracy of dosing, prolonged residence time, improved nasal absorption and avoid typical side effects associated with oral administration of domperidone.

Keywords: Insitu nasal gel, Domperidone Maleate, Gelling Temperatur.