A REVIEW ON FORMULATION ASPECTS OF SOLID DISPERSIONS
Dr. S. R. Shahi, Khan Arshiya*, Pravin Bhalerao and Ade Pavan
Drugs emerging in drug discovery process often are poorly water soluble. Therefore, techniques which overcome this problem needs to be explored. Improved solubility will lead better absorption and thereby increased bioavailability. Solid dispersions form an excellent formulation alternative for such drugs. Solid dispersion molecularly disperses the drug in carrier and thus improve solubility and dissolution rate of the drug and carrier respectively. This review gives an insight on the formulation aspects of solid dispersions. The article is based on formulation requirements and the mechanism of drug release from solid dispersions. A comprehensive knowledge on the carriers used in solid dispersions and the interactions taking place in solid dispersion in the drug-carrier system is discussed. Basic features of solid dispersion have also been stated but the main focus is to understand solid dispersions from interaction point view of carriers used. This review will thus help in understanding to develop an optimized solid dispersion.
Keywords: Solid dispersions, Types of solid dispersions, Drug release, Carriers, Polymers, Drug-polymer interactions.
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