EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

QUALITY ANALYSIS STUDY ON MARKET PREPARATION OF METFORMIN TABLET AVAILABLE IN BANGLADESH

Md. Shariful Islam*, Tawfiqa Rahman, Md. Saroar Hosan, Sabrina Sajin Shipra, Md. Abdur Rahaman Miah, Adhora Mahbub and Md. Hasan-Al Jubayed

ABSTRACT

Tablet is a pharmaceutical unit dosage form. Various brands of same dosage forms are available in the market with the common claim that they are all complies the standard pharmacopoeia. Total five different brands of Metformin tablets from different manufacturers were selected in the study. Dissolution testing was conducted according to USP from each brand for 25 minutes by using dissolution testing apparatus USP type-I (Basket). The tablets were subjected to various post-production tests such as hardness, physical parameters like weight variation, chemical parameters like assay, disintegration also considered for this study. Assay and Dissolution was checked by using a UV Spectrophotometer where Phosphate Buffer was used as dissolution medium. From the analysis of the results, it was observed that there was a considerable variation in the dissolution rates and also in the pattern of hardness, assay, friability, disintegration and weight of tablets. The disintegration, hardness and weight variation test of Tablets were performed as mentioned in BP or USP in world class equipment. All the results of these tests were matched USP standards. If the disintegration time, hardness, weight variation of Tablets varies a lot from the standard time, the tablets will not be able to show the desired therapeutic effect on time in the patients, which in result will increase the risk of patients. From the analysis of the results, this was observed that there was a considerable variation in the dissolution rates and also in the pattern of hardness, assay, friability, disintegration and weight of tablets.

Keywords: Metformin tablets, disintegration & dissolution, analysis, USP, comply.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia