EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A CASE OF PIPERACILLIN-TAZOBACTAM INDUCED ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS

Dr. Pallavi Kawatra*, Dr. Yashasvi Suvarna, Dr. Cuckoo Aiyappa and
Dr. Sanjay C Desai 

ABSTRACT

Acute generalised exanthematous pustulosis (AGEP) is a rare cutaneous adverse drug reaction with an incidence of 1-5 patients per million per year. 80% of the cases have been attributed to antibiotics. A 50 year old diabetic male, presented with complaints of right lower limb pain and wound on the right heel and inter digital web space infection of the right foot since 15 days. On the basis of Ankle Brachial Index & Angiogram, a diagnosis of Ilio-femoral-popliteal disease was ascertained and thus revascularisation was done. Postoperatively, he was started on Inj Piperacillin-Tazobactam 4.5 gm bd. Following the second dose of Inj. Piperacillin-Tazobactam he developed painful exanthematous scaling rashes with pustules on the trunk and upper limbs but no involvement of the lower limbs. Except for a rise in temperature [101 F], rest of the vitals were stable and the blood reports showed neutrophilia (N-83%). The causality assessment of this reaction as per the Naranjo’s Scale was found to be 7 (Probable). Although rare, the clinicians should be aware of such an entity as knowledge of the clinical features and course of this reaction can prevent unnecessary therapeutic measures.

Keywords: AGEP, cutaneous, Adverse drug reaction, antibiotics.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )