SYNTHESIS AND SCREENING OF NOVEL SUBSTITUTED INDANE 2, 3- DIONE FOR ANTICONVULSANT ACTIVITY
Mathew George, Lincy Joseph and Mincy Mathew*
Indane 2, 3- dione (isatin) derivatives have shown wide range of activities like antibacterial, antifungal,
anticonvulsant etc. Particularly isatin nucleus has a lactam structure which is an important part of antiepileptic
drugs (AEDs).For the synthesis of various derivatives of indane 2,3 –diones , first it was treated with ethyl
chloroacetate and the resultant product was then treated with hydrazine hydrate and the hydrazides thus obtained
was allowed to react with different aldehydes for the corresponding hydrazones. Hydrazones were then treated with
chloramine T for the required product.
Keywords: Indane 2, 3-dione, Hydrazones, 1, 3, 4-oxadiazole, Anticonvulsant activity.
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