EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF MARSILEA QUADRIFOLIA LINN.

*Gomathi Venkatachalam and Jaykar Balasundaram

ABSTRACT

The present study was carried out to evaluate the Diuretic activity of the leaves of the plant Marsilea quadrifolia Linn based on the traditional use of the plant. The plant leaves were collected, dried and then subjected to Soxhlet extraction with various solvents from non-polar to polar. The extraction was carried out for 72 hrs with petroleum ether and ethanol. The aqueous extraction was carried out by cold maceration process. Then the extracts were subjected to preliminary phytochemical screening. Based on the preliminary phytochemical studies, the ethanolic extract was selected for the evaluation of Diuretic activity by in -vivo, Lipschitz test method using Frusemide as the standard drug. The ethanolic extract of M.quadrifolia showed a dose-dependent increase in both water (urine) excretion and excretion of Na+, K+, Cl- ions. From the results, both the doses of ethanolic extract (200mg/kg & 400mg/kg) showed significant diuretic activity by increasing the total urine output and increasing the excretion of Na+, K+, Cl- salts. Thus this plant can be used as a diuretic drug source and it seems to have lesser side effects when compared to that of the synthetic drugs.

Keywords: Diuretics, Marsilea quadrifolia Linn, Soxhlet extraction, Lipschitz test, Frusemide.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )