SYNTHESIS, CHARACTERISATION AND BIOLOGICAL STUDIES ON Cu (II) and Mn (II) QUINOLINE SCHIFF BASE COMPLEXES
*N. Sudha and R. Karunamoorthi
Schiff bases play an important role in inorganic chemistry as they easily form stable complexes with most transition metal ions. The preparation and study of inorganic compounds containing biologically important ligands Nora H. Al-Shaalan (2011). The fact that copper, magnesium, iron, zinc and manganese are important metallic elements and display great biological activity when associated with certain metal–protein complexes, participating in oxygen transport, electronic transfer reactions, has produced enormous curiosity in the study of systems containing these metals.[10-11] Molecules containing donor-acceptors such as Schiff bases have ability to serve as polymeric ultraviolet stabilizers, laser dyes. The present work is focused on the study of co-ordination behaviour of thiosemicarbazone Schiffbase with hydrated Cu(II) and Mn(II) chlorides. Analytical and spectral data confirmed the structure of the complexes. Also absorption at 305nm might be due to the extended conjugation of the ring or may be due to the ring residue. Antibacterial and Antifungal activities were carried out using Disc diffusion method and the compounds were found to be active. A number of metal coordination complexes of Schiff bases have been suggested as antibacterial, antifungal, cytotoxic, anti-inflammatory and Cytostatic agents.[12-14]
Keywords: Schiff base complexes, Antibacterial activity, Antifungal activity.
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