RECENT ADVANCES IN THE SYNTHESIS OF TELMISARTAN: A REVIEW
Premchand Patil, Deepak V. Nagarale, and Dr. Bhata R. Chaudhari*
Telmisartan is an effective, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT1) receptor that is
indicated for the treatment of essential hypertension. It selectively inhibits stimulation of the AT1 receptor by
angiotensin II without affecting other receptor systems involved in cardiovascular regulation. Very high
lipophilicity a unique feature of telmisartan attached with a high volume of distribution indicate that the compound
offers the clinically important advantage of good tissue penetration. It also activates peroxisome proliferator –
activated receptor c (PPAR-c) and increase adiponectin protein content in adipocytes. As a result they may develop
insulin sensitivity. It belongs to a class II drug in BCS categorization i.e. low solubility and high permeability. One
of the major troubles with this drug is its low solubility in biological fluids which results into poor bioavailability
after oral administration to improve the aqueous solubility and dissolution rate of the telmisartan solid dispersions
of drug using different methods were prepared and investigated.
Keywords: Telmisartan was discovered and commercialized by Boehringer Ingelheim.
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