CHEMICAL AND POTENTIAL BIOLOGICAL PERSPECTIVES OF GENUS SENECIO [ASTERACEAE]
Darshan Singh*, Satish Chandra Sati and Manisha Dobhal Sati
Ethnopharmacological Relevance: The plant of the genus Senecio [Astereaceaes] is widely distributed ,and have long been used in folk medicine for the treatment of various ailments particularly treatment of dysentery, conjunctivitis, infections, rheumatism, cancer, cough suppressant, asthma, bronchitis, eczemainflammation, and muscular pain. Aim of the Review: In present review we emphasized the recent progress in the chemistry and biologyog this genus as well as its traditional uses.This database may provide guidance for researchers, chemists and herbologists for further investigation in the field. Materials and Methods: All literature available on the genus Senecio was collected via electronic search [using Scifinder, Google scholar, Scirus and Web of science], books, thesis and journals. Results: Ethnobotanical uses of different species of genus Senecio have been reported from China, Pakistan, India, Malasiya,Australia and Nepal for their different types of ailments,Genus Senecio possesses different chemical constituents including alkaloids,glycosides, sugar, sesquiterpenoids, monoterpenoids, diterpenoids, triterpenoids, flavonoids,coumarins, and some other compounds.Crude extract, fraction, and isolated secondary metabolities of genus Senecio have shown a wide range of pharmacological activities including antibacterial, antifungal, antifeedant,antioxidant and cholinesterase inhibiting activities. Conclusion: The leaves and roots of Senecio plants have been used for the treatment of dysentery, conjunctivitis, infections, rheumatism, fever in the folk medicine system for years without any adverse effect.However there is a need to search for individual secondary metabolities responsible for these actions and study their mode of actions, and physiological pathways in sufficient details.
Keywords: The genus Senecio, which belongs to the tribe Senecioneae.
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