EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PILOT AND ACUTE TOXICITY STUDIES ON TARTRAZINE IN ALBINO RATS

*Elekima Ibioku, Nwachuku Edna Ogechi and Nduka Nsirim

ABSTRACT

Pilot and acute toxicity studies were carried out to determine the LD100 and LD50 of tartrazine administered intraperitoneally and orally. A total of 68 albino rats weighing approximately 150g were used. 10 rats were used for the determination of LD100 of tartrazine administered intraperitoneally with doses of 0.0g/kg, 1.68g/kg, 3.33g/kg, 5.0g/kg, 6.67g/kg, 8.33g/kg, 10.0g/kg, 13.33g/kg, 15.0g/kg and 16.67g/kg. Likewise, 10 rats were also used in the determination of LD100 of tartrazine administered orally with doses of 0.0g/kg, 2.5g/kg, 5.0g/kg, 10.0g/kg, 15.0g/kg, 20.0g/kg, 22.5g/kg, 30.0g/kg, 35.0g/kg and 40.0g/kg. In the acute study, rats for intraperitoneal and oral administration were classified into six groups. Each group had a total of four rats. The intraperitoneally treated groups were designated Ai, Bi, Ci, Di, Ei and Fi and were treated with 0.0g/kg, 1.68g/kg, 3.33g/kg, 5.0g/kg, 6.67g/kg, 8.33g/kg respectively while that of oral were designated Ao, Bo, Co, Do, Eo and Fo were also treated with 0.0g/kg, 2.5g/kg, 5.0g/kg, 10.0g/kg, 15.0g/kg, 20.0g/kg respectively after LD100 determination. From studies, the LD100 were found to be 8.33g/kg and 20.0g/kg while the LD50 were found to 5.83g/kg and 11.25g/kg for intraperitoneally and orally treated rats respectively. Based on the LD50 obtained, tartrazine could be classified as practically non-toxic substance according Matsumura toxicity rating of chemical when administered intraperitoneally or orally.

Keywords: Pilot, Acute, toxicity, Tartrazine, LD100, LD50.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: MARCH ISSUE PUBLISHED

    MARCH 2024 issue has been successfully launched on MARCH 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia