EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF EUDRAGIT® POLYMERS (RS 100 AND RL100) ON THE RELEASE OF DICLOFENAC SODIUM FROM MICROCAPSULES

*Sonika Rani Jangra and D.C. Bhatt

ABSTRACT

The controlled release dosage forms have made significant progress in terms of clinical efficacy and patient compliance. The micro-encapsulation is one of the widely accepted technique for the controlled drug delivery. Polymers used as in formulation play a vital role in controlling the drug release from the microcapsules. Diclofenac Sodium, is a widely used nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation or for reducing pain in certain conditions. It is used commonly to treat mild to moderate postoperative or post traumatic pain, when inflammation is present. Diclofenac Sodium is BCS class II drug and it was microcapsulated by the solvent evaporation technique using a nonaqueous solution of polymers Eudragit® RS100 and Eudragit® RL100 to achieve its sustained release from the microcapsules at a slower rate. The effect of two copolymers Eudragit® RS100 and Eudragit® RL100 was investigated using various drug polymer ratio. These microcapsules were free-flowing in nature with smooth surface, spherical shape as examined by scanning electron microscopy. The data obtained from in vitro dissolution profiles of drug formulations were compared using different release kinetics models and the regression coefficients were compared.

Keywords: Microencapsulation, Eudragit, Sustained Release, Diclofenac Sodium.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )