EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT AND EVALUATION OF TRANSDERMAL SYSTEMS CONTAINING BISOPROLOL FUMARATE

Sri. Srikanth*, Dr. Somashekar Shyale

ABSTRACT

Hypertension is a major disease caused by mental stress and work tension. To duplicate the benefits of intravenous drug infusion without its potential hazards, The novel drug delivery system has brought renaissance into the pharmaceutical industry for controlled drug delivery. In this investigation it was planned to formulate transdermal formulations containing Bisoprolol fumarate (hydrophilic) using two natural gums viz.., Xanthan gum and Almond gum as a reservoir gels planned to characterize the candidate drugs for physico-chemical properties. Membrane-moderated TTS was prepared with rate controlling Eudragit RL 100 polymer, with reservoir gels, and provided with a backing laminate. The films was characterized by WVT studies and SEM photomicrographs. Further, in vitro permeation of the candidate drugs was conducted in keshary-chien diffusion cells across depilated abdominal skin of male Swiss albino rat. The data was corrected with Hayton-chien equation, to remove any sample induced bias. Also the data was subjected to regression analysis and ANOVA. A value of p<0.05 shall be considered statistically significant. Various permeation parameters like, flux, diffusivity, and permeability coefficient was determined. Stability of the TTS of Bisoprolol fumarate also studied at 40 ºC / 75 %RH.

Keywords: Bisoprolol fumarate, Xanthan gum, Almond gum, Eudragit RL 100.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )