DEVELOPMENT AND EVALUATION OF TRANSDERMAL SYSTEMS CONTAINING BISOPROLOL FUMARATE

Sri. Srikanth*, Dr. Somashekar Shyale

ABSTRACT

Hypertension is a major disease caused by mental stress and work tension. To duplicate the benefits of intravenous drug infusion without its potential hazards, The novel drug delivery system has brought renaissance into the pharmaceutical industry for controlled drug delivery. In this investigation it was planned to formulate transdermal formulations containing Bisoprolol fumarate (hydrophilic) using two natural gums viz.., Xanthan gum and Almond gum as a reservoir gels planned to characterize the candidate drugs for physico-chemical properties. Membrane-moderated TTS was prepared with rate controlling Eudragit RL 100 polymer, with reservoir gels, and provided with a backing laminate. The films was characterized by WVT studies and SEM photomicrographs. Further, in vitro permeation of the candidate drugs was conducted in keshary-chien diffusion cells across depilated abdominal skin of male Swiss albino rat. The data was corrected with Hayton-chien equation, to remove any sample induced bias. Also the data was subjected to regression analysis and ANOVA. A value of p<0.05 shall be considered statistically significant. Various permeation parameters like, flux, diffusivity, and permeability coefficient was determined. Stability of the TTS of Bisoprolol fumarate also studied at 40 ºC / 75 %RH.

Keywords: Bisoprolol fumarate, Xanthan gum, Almond gum, Eudragit RL 100.