FORMULATION AND IN VITRO EVALUATION OF PIOGLITAZONE HYDROCHLORIDE MOUTH DISSOLVING TABLETS

Bandi Anitha* and Polepaka Ajaykumar

ABSTRACT

The purpose of this research work was to develop antidiabetic mouth dissolving tablets of Pioglitazone HCL thereby enhancing the dissolution rate. Tablets containing Pioglitazone, sodium starch glycolate & crospovidone, Croscarmellose sodium as superdisintegrants were prepared by wet granulation & direct compression techniques. The tablets were evaluated for weight variation, hardness, percentage friability, wetting time and disintegration time were showed acceptable results. Formulations F5 and F9 showed disintegration time of 23 and 22 sec respectively. Dissolution was performed in pH 1.2 Hcl buffer and formulations F5 showed maximum drug release within 30 min and drug release from F9 was more than that of the marketed drug. Hence, it could be concluded that formulation F9 showed good drug release than marketed drug. The results compared for both the technologies showed that the Pioglitazone HCL tablets prepared using wet granulation was found to have good technological properties and satisfying and reproducible drug dissolution profiles. Moreover the drug release was found to be comparable to the marketed dispersible tablet.

Keywords: Mouth dissolving tablets, Pioglitazone, Direct compression, Wet granulation, dissolution enhancement.